Since its inception in 2015, the BioExcel CoE has had a large and measurable impact on science, technology, and education. Our work exemplifies that producing high-quality and user-friendly software and spreading necessary expertise are the main pathways towards achieving broad societal impact. In doing so we have built and are continuously expanding a strong community. We have enabled user needs to drive HPC software development, and educated users to creatively adapt to the abilities and limitations of HPC systems for solving scientific challenges through better software, and better use of it. These activities form the foundation on which we have developed the roadmap of BioExcel activities.