Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
Here, we report cryo-electron microscopy (cryo-EM) structures of the proton-activated Gloeobacter violaceus ligand-gated ion channel (GLIC) under three pH conditions. Decreased pH was associated with improved resolution and side chain rearrangements at the subunit/domain interface, particularly involving functionally important residues in the β1–β2 and M2–M3 loops.
Integrating quantitative proteomics with accurate genome profiling of transcription factors by greenCUT&RUN
Genome-wide localization of chromatin and transcription regulators can be detected [...]
Enabling the execution of large scale workflows for molecular dynamics simulations
In this paper we present an approach to support biomolecular researchers in the development of complex workflows. Our approach is based on the orchestration of computational building blocks for Molecular Dynamics simulations through an efficient workflow management system that has already been adopted in many scientific fields to run applications on multitudes of computing backends.
Implementing FAIR Digital Objects in the EOSC-Life Workflow Collaboratory
To serve the needs of this established and diverse community, EOSC-Life has developed WorkflowHub as an inclusive workflow registry, agnostic to any Workflow Management System (WfMS). WorkflowHub aims to incorporate their workflows in partnership with the WfMS, to embed the registration of workflows in the community processes, e.g. based on pre-existing workflow repositories.
Semantic micro-contributions with decentralized nanopublication services
We present here an approach to use nanopublications and a decentralized network of services to allow users to directly publish small Linked Data statements through a simple and user-friendly interface, called Nanobench, powered by semantic templates that are themselves published as nanopublications.
Ultrafast structural changes within a photosynthetic reaction centre
Photosynthetic reaction centres harvest the energy content of sunlight by [...]
