The Laboratoire de Biochimie Théorique has developed original tools for visualization and analysis of protein structures, focusing on advanced environments such as virtual reality helmets and display walls. This project aims to apply and improve the Unitymol approach to computational analysis, visualization and modeling of redox signal networks. The aim of this project is to develop an interactive bioinformatics tool for the visualization of huge proteomic datasets of redox signaling networks. These will be made intelligible through a large and high-resolution visualization wall to analyze network dynamics, based on quantitative and time-resolved proteomic technology that allows detection of nitrosylation and glutathionylation. Structural interpretations will be enabled by an automated modeling pipeline linking to various human mitochondrial diseases. We are seeking a highly motivated candidate to develop and implement a next-generation bioinformatics visualization platform.

The candidate will develop a tool for modeling the 3D structure of all modified proteins of the target organism, the alga Chlamydomonas Reinhardtii. The generated data will be integrated into the visualization of the redox networks. We will achieve this through a graphical representation of the redox system and its evolution over time, with the ability to explore connections between different systems. The foundations for the project have already been laid (see e.g. UnityMol), so we have a well-defined framework to get started. This position is a unique training opportunity in a multidisciplinary environment that brings together several leading groups in academic research.

Duration of contract: 18 months starting ASAP
Expected date of employment: January 1, 2022
Remuneration: between € 2,140 and € 3,954 gross per month depending on experience

For more information on how to apply, visit Marc Baaden’s website.

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