Dear reader reader,

Our third newsletter of the Integrative Modelling series is out! If you missed the first ones, you can luckily still find them here under the "Integrative Modelling IG" section.

This month, we have again a very nice program: 

Two recent papers that we happily share we you in case you missed them, the interview of Matteo Dal Peraro who created power, a framework designed to solve structural biology problems specifically related to the assembly of large molecular systems, and a highlight of the new version of Chimera, ChimeraX, that focuses even more on Integrative modelling data!

We are also excited to communicate the date of the 1st BioExcel community forum, a 2-days event where members of the main Interest Groups have the opportunity to meet and exchange around the main topics of BioExcel. Of course, you are the first target of this event and we look forward to meeting you the 22nd and 23rd of November in Amsterdam. More details on the program and the venue can be found here.

We hope to trigger some discussions on the interest group and really encourage you to contribute to the upcoming issues of our newsletter by suggesting events/articles on the IG-IM forum.

As usual, a digest of all those posts can be found on the main page of our community.

At last, thanks to the great work of Vera Matser at ISCB/ECCB 2017, we would like to welcome our new members: Alexandre, Camilo, Carmen, David, Dwitiya, Eugenia, Gal, Hana, Marc, Pooya, Ravi and Sara. Keep tuned folks, we have some great news coming up soon to share with you!


Lights on... Matteo Dal Peraro - creator of power

Matteo Dal Peraro graduated in Physics at the University of Padua in 2000. He obtained his Ph.D. in Biophysics at the International School for Advanced Studies (SISSA, Trieste) in 2004. He then received postdoctoral training at the University of Pennsylvania (Philadelphia) under the guidance of Prof. M. L. Klein. He was nominated Tenure Track Assistant Professor at the EPFL School of Life Sciences in late 2007.
His research at the Laboratory for Biomolecular Modeling (LBM), within the Interfaculty Institute of Bioengineering (IBI), focuses on the multiscale modeling of large macromolecular systems... 
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P. Kastritis et al. (2017)
Capturing protein communities by structural proteomics in a thermophilic eukaryote.

Molecular System Biology, 13(7):936.
SUMMARY: The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive. Here, we show that crude cellular extracts of a eukaryotic thermophile, Chaetomium thermophilum, retain basic principles of cellular organization. Using a structural proteomics approach, we simultaneously characterized the abundance, interactions, and structure of a third of the C. thermophilum proteome within these...Read more

A.P. Joseph, G. Polles, F. Alber, and M. Topf. (2017)
Integrative modelling of cellular assemblies.
Curr. Opin. Struct. Biol., Volume 46, 102-109.
SUMMARY: A wide variety of experimental techniques can be used for understanding the precise molecular mechanisms underlying the activities of cellular assemblies. The inherent limitations of a single experimental technique often requires integration of data from complementary approaches to gain sufficient insights into the assembly structure and function. Here, we review popular computational approaches for integrative modelling of cellular assemblies, including protein complexes and genomic... Read more


Tips & Tricks

Today, we will talk about ChimeraX, the new version of Chimera that comes with exciting new features, starting to address on Integrative and Hybrid methods for molecular modelling..!
Read more about it here!

Do not hesitate to share your own tips & tricks!