IM-IG

Integrative Modelling interest group related content.


Paper: Disentangling constraints using viability evolution principles in integrative modeling of macromolecular assemblies

Abstract Predicting the structure of large molecular assemblies remains a challenging task in structural biology when using integrative modeling approaches. One of the main issues stems from the treatment of heterogeneous experimental data used to predict the architecture of native complexes. We propose a new method, applied here for the […]


Paper: Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex

Abstract The membrane ring that equatorially circumscribes the nuclear pore complex (NPC) in the perinuclear lumen of the nuclear envelope is composed largely of Pom152 in yeast and its ortholog Nup210 (or Gp210) in vertebrates. Here, we have used a combination of negative-stain electron microscopy, nuclear magnetic resonance, and small-angle […]


Paper: Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop

Abstract Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical information. We describe here the proceedings and conclusions from the first wwPDB Hybrid/Integrative Methods Task Force Workshop held at the European Bioinformatics Institute in Hinxton, UK, on October 6 […]